Research Experience
2020 – : Professor, College of Chemistry and Molecular Engineering, Peking University
2020 – : Principal Investigator, PKU-Tsinghua Center for Life Sciences
2010 –2020 : Principal Investigator, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences
2008 –2010: Assistant Professor, Department of Biochemistry, University of Missouri, Columbia
2003 –2008: Postdoc, Laboratory of Chemical Physics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health (with
G. Marius Clore)
2003: Ph.D. degree in Biochemistry, University of Maryland, Baltimore County (mentored by
Michael F. Summers)
1998: B.S. degree in Biology, Zhejiang University
Research Interests
- □Method development of paramagnetic NMR
- Selected Publications
- Gong Z, Charles DS, Tang C (2018) Theory and practice of using solvent paramagnetic relaxation enhancement to characterize protein conformational dynamics. Methods, 148:48-56
- Jiang WX, Gu XH, Dong X, Tang C. (2017). Lanthanoid tagging via an unnatural amino acid for protein structure characterization. J Biomol NMR, 67:273-282
- Gong Z, Gu XH, Guo DC, Wang J, Tang C. (2017). Protein structural ensembles visualized by solvent paramagnetic relaxation enhancement. Angew Chem Int Ed, 56:1002-1006
- Liu Z, Gong Z, Dong X, Tang C. (2016) Transient protein-protein interactions visualized by solution NMR. BBA Proteins and Proteomics, 1864:115-122
- Xing Q, Huang P, Yang J, Sun JQ, Gong Z, Dong X, Guo DC, Chen SM, Yang YH, Wang Y, Yang MH, Yi M, Ding YM, Liu ML, Zhang WP, Tang C. (2014) Visualizing an ultra-weak protein-protein interaction in phosphorylation signaling. Angew Chem Int Ed, 53:11501-11505
- □Method development for integrative structural biology refinement, to better utilize the data from small angle scattering, single-molecular FRET, and chemical crosslinking, etc.
- Selected Publications
- Gong Z, Ye SX, Tang C. (2020) Tightening the crosslinking distance restraints for better resolution of protein structure and dynamics. Structure, DOI: 10.1016/j.str.2020.07.010
- Gong Z, Ye SX, Nie ZF, Tang C. (2020) The conformational preference of chemical crosslinkers determines the crosslinking probability of reactive protein residues. J Phy Chem B, 123:4446-4453
- Tang C, Gong Z. (2020) Integrating Non-NMR Distance restraints to augment NMR depiction of protein structure and dynamics. J Mol Biol, 432:2913-2929
- Liu Z, Gong Z, Cao Y, Ding YH, Dong MQ, Lu YB, Zhang WP, Tang C. (2018). Characterizing protein dynamics with integrative use of bulk and single-molecule techniques. Biochemistry, 57:305-313
- Ding YH, Gong Z, Dong X, Liu K, Liu Z, Liu C, He SM, Dong MQ, Tang C. (2017). Modeling protein excited-state structures from "over-length" chemical cross-links. J Biol Chem, 292:1187-1196
- □To understand how post-translational/transcriptional modifications impact the structure and dynamics of proteins and RNAs, with an emphasis on ubiquitin phosphorylation and RNA methylation
- Selected Publications
- Tang C, Zhang WP. (2020) How phosphorylation by PINK1 remodels the ubiquitin system, a perspective from structure and dynamics. Biochemistry, 59:26-33
- You ZY, Jiang WX, Qin LY, Gong Z, Wan W, Li J, Wang YS, Zhang HT, Peng C, Zhou TH, Tang C, Liu W. (2019) Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. Nat Commun, 10:5792
- Huang JB, Dong X, Gong Z, Qin LY, Yang S, Zhu YL, Wang X, Zhang DL, Zou TT, Yin P, Tang C. (2019) Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein Cell, 10:272-284
- Dong X, Gong Z, Lu YB, Liu K, Qing LY, Ran ML, Zhang CL, Liu Z, Zhang WP, Tang C. (2017). Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch. Proc Natl Acad Sci, USA, 114:6770-6775
- Liu Z, Gong Z, Jiang WX, Yang J, Zhu WK, Guo DC, Zhang WP, Liu ML, Tang C. (2015) Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition. eLife, 4:e05767
