研究兴趣:
高分子化学、可降解生物医用高分子材料、生物偶联、生物医药工程
教育经历:
- 2006 – 2011 博士, 美国伊利诺伊大学香槟分校材料系
- 2002 – 2006 学士,kaiyun体育官方网站
工作经历
- 2022 – 至 今 博雅特聘教授,kaiyun体育官方网站
- 2020 – 至 今 副主编,美国化学会期刊Biomacromolecules
- 2020 – 2022 副教授(长聘),kaiyun体育官方网站
- 2014 – 2020 助理教授,kaiyun体育官方网站
- 2011 – 2014 博士后,Scripps研究所化学系
主要获奖及荣誉
- 中国化学会-英国皇家化学会青年化学奖(2023)
- 药明康德生命化学研究奖学者奖(2022)
- 国家杰出青年科学基金(2021)
- kaiyun体育官方网站青年教师基本大赛一等奖暨最受员工欢迎奖(2020)
- 中国化学会高级会员(2020)
- ACS PMSE Young Investigator(2020)
- 日本高分子学会(SPSJ)International Leading Young Scientist(2020)
- 中国化学会高分子青年学者奖(2019)
- 中国化学会青年化学奖(2017)
- 国家优秀青年科学基金(2017)
- ACS-AkzoNobel Award for Outstanding Graduate Research in Polymer Chemistry(2013)
- IUPAC Prize for Young Chemists, Honorable Mention(2012)
- Damon Runyon癌症研究基金会博士后奖学金 (2011-2014)
- 伊利诺伊大学材料系Racheff-Intel Award (Top Winner, 2011)
- 第34届国际化学奥林匹克竞赛金牌(2002)
近五年代表论文
- Shuo Wang, Ming-Yuan Lu, Si-Kang Wan, Chun-Yan Lyu, Zi-You Tian, Kai Liu, and Hua Lu*, “Precision Synthesis of Polysarcosine via Controlled Ring-Opening Polymerization of N-Carboxyanhydride: Fast Kinetics, Ultrahigh Molecular Weight, and Mechanistic Insights”, J. Am. Chem. Soc. 2024, 146, 5678–5692.
- Jianhua Lu, Yuanhao Dai, Yahui He, Ting Zhang, Jing Zhang, Xiangmei Chen, Changtao Jiang, and Hua Lu*, “Organ/Cell-Selective Intracellular Delivery of Biologics via N-Acetylated Galactosamine-Functionalized Polydisulfide Conjugates”, J. Am. Chem. Soc. 2024, 146, 3974–3983.
- Guangqi Wu, Haisen Zhou, Jun Zhang, Zi-You Tian, Xingyi Liu, Shuo Wang, Connor W. Coley, and Hua Lu*, “A High-Throughput Platform for Efficient Exploration of Functional Polypeptide Chemical Space”, Nat. Synth. 2023, 2, 515-526.
- Y. Hu, Z.-Y. Tian, W. Xiong, D. Wang, R. Zhao, Y.Xie, Y.-Q.Song, J. Zhu, and H. Lu*; “Water-Assisted and Protein-Initiated Fast and Controlled Ring-Opening Polymerization of Proline N-Carboxyanhydride”, Natl. Sci. Rev. 2022, 9, nwac033.
- Jianhua Lu, Zhun Xu, Hailin Fu, Yao Lin, Huan Wang, and Hua Lu*, “Room-Temperature Grafting from Synthesis of Protein–Polydisulfide Conjugates via Aggregation-Induced Polymerization”, J. Am. Chem. Soc. 2022, 144, 15709-15717.
- C. Dong†; G. Wu†; C. Chen; X. Li; R. Yuan; L. Xu; J. Zhang; H. Guo; J. Zhang; H. Lu*, and F. Wang*; “Site-specific Conjugation of a Selenopolypeptide to Alpha-1-antitrypsin Enhances Oxidation Resistance and Pharmacological Properties”, Angew. Chem. Int. Ed. 2022, 61, e2021152. (†equal contribution) (Hot Paper).
- Z.-Y. Tian; Z. Zhang; S. Wang; and H. Lu*, “A Moisture-Tolerant Route to Unprotected α/β-Amino Acid N-Carboxyanhydrides and Facile Synthesis of Hyperbranched Polypeptides”, Nat. Commun. 2021, 12, 5810.
- W. Xiong; W. Chang; D. Shi; L. Yang; Z.-Y. Tian; H. Wang; Z. Zhang; X. Zhou; E.-Q. Chen,* and H. Lu*, “Geminal Dimethyl Substitution Enables Controlled Polymerization of Penicillamine-Derived β-Thiolactones and Reversed Depolymerization”, Chem 2020, 6, 1831-1843. (Highlighted by Chem)
- Jingsong Yuan, Dong Shi, Yi Zhang, Jianhua Lu, Letian Wang, Er-Qiang Chen,* and Hua Lu*, “4-Hydroxy-L-Proline as a General Platform for Stereoregular Aliphatic Polyesters: Controlled Ring-Opening Polymerization, Facile Functionalization, and Site-Specific Bioconjugation”, CCS Chem. 2020, 2, 236-244.
- J. Lu; H. Wang; Z.-Y. Tian; Y. Hou; and H. Lu*, “Cryopolymerization of 1,2-Dithiolanes for the Facile and Reversible Grafting-from Synthesis of Protein-Polydisulfide Conjugates”, J. Am. Chem. Soc. 2020, 142, 1217-1221. (Selected as JACS Early Career Investigators Virtual Issue)