Feb. 2024

Biologics, including proteins and antisense oligonucleotides (ASOs), face significant challenges when it comes to achieving intracellular delivery within specific organs or cells through systemic administrations. In this work, we develop a novel approach for delivering proteins and ASOs to liver cells, both in vitro and in vivo, using conjugates that tethering N-acetylated galactosamine (GalNAc)-functionalized, cell-penetrating polydisulfides (PDS). These conjugates hold tremendous potential in overcoming the various biological barriers encountered during systemic and cell-specific delivery of biomacromolecular cargos, opening new avenues for the diagnosis and treatment of a range of liver-targeting diseases. This is the third first-authored JACS paper of Jianhua Lu, great work! [Link]