原定于6月4日（周一） 下午15:30—16:30的该期无机化学论坛因故取消，谢谢各位老师同学的关注！

报告人: Laura L. Anderson, Professor,

Department of Chemistry, University of Illinois at Chicago
 

时间：2018年6月4日（周一） 下午15:30—16:30

地点：kaiyun体育官方网站化学公司A区717报告厅.

While the use of nitrones as dipolar cycloaddition reagents and N-hydroxyamines as heterocyclic precursors is well-established, the breadth of pericyclic reactions where these compounds can be applied has been limited by the dearth of methods available to access alkenyl-substituted derivatives. Our laboratory has demonstrated that copper-promoted alkenylation reactions can be tuned for the synthesis of N-alkenylnitrones and N,O-dialkenylhydroxylamines.1,2 These tools have allowed us to investigate the reactivity of these novel reactive intermediates in electrocyclization processes and [3,3]-sigmatropic rearrangement cascade reactions, respectively.2-4 The scope these new methods, our understanding of these processes, and the chemical diversity that can be rapidly achieved using these transformations will be discussed.

REFERENCES
1. (a) Mo, D.-L.; Wink, D. J.; Anderson, L. L. Org. Lett. 2012, 14, 5180; (b) Pecak, W. H.; Son, J.; Burnstine, A.J.; Anderson, L. L. Org. Lett. 2014, 16, 3440.   

2. (a) Son, J.; Reidl, T. W.; Kim, K. H.; Wink, D. J.; Anderson, L. L. Angew. Chem. Int. Ed. 2018, doi:10.1002/anie.201800908.
3. (a) Son, J.; Kim, K. H.; Mo, D.-L.; Wink, D. J.; Anderson, L. L. Angew. Chem. Int. Ed. 2017, 56, 3059; (b) Reidl, T. W.; Son, J.; Wink, D. J.; Anderson, L. L. Angew. Chem. Int. Ed. 2017, 56, 11579.

4. Wang, H.-Y.; Anderson, L. L. Org. Lett. 2013, 15, 3362