报告人：Prof. Naoki Sugimoto, Konan University, Japan

时间：4月11日（周四）下午1:30 – 2:30

地点：A717报告厅

内容提要

Non-canonical structures of nucleic acids such as a triplex and a quadruplex are stabilized under conditions that mimic the crowded cellular conditions and have been detected in cells. It is possible that the non-canonical structures act as “functional codes” triggered by different molecular environments that regulate gene expression epigenetically. As sequences capable of forming the non-canonical structures are found in telomeres and promoter regions of known oncogenes, alterations of the non-canonical structures could play important roles in the progression of cancer and in other diseases. In this lecture, I will talk and discuss how the structures, topologies, and functions of nucleic acids differ under various conditions such as highly crowded environments and affect the gene expression.

报告人简介

Prof. Naoki Sugimoto is the Director and Professor of Frontier Institute for Biomolecular Engineering Research (FIBER), and Professor of graduate school of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, Japan. He obtained his Ph.D. from Kyoto University in 1985, and was a postdoc and research associate at University of Rochester from 1985-1988. He joined Konan University in 1988. His research interests include biophysical chemistry, biomaterials, nanobio-engineering, molecular design, biofunctional chemistry, and biotechnology.