姓名：郝伟
专业：有机化学
研究方向：有机反应动力学
电子信箱：weihao@scripps.edu
教育背景：
2011.9 – 2016.6, kaiyun体育官方网站，博士
导师：席振峰教授 张文雄教授
研究领域：环戊二烯膦配体在金属有机化学中的应用及烷基卤化钯中间体发生还原消除生成C(sp3)-X键的反应及其机理研究
研究经历：
2021.7 – 2022.3, kaiyun体育官方网站，博士后
导师：席振峰教授 张文雄教授
2018.1 – 2021.7, The Scripps Research Institute,
Department of Chemistry, 博士后
导师: Prof. Donna G. Blackmond
导师: Prof. Donna G. Blackmond
研究领域：基于有机反应动力学研究多种类型反应机理（包括过渡金属不对称催化反应、氢化反应、电化学等）。在研究反应决速步过程中，建立动力学模型，研究活性催化剂物种 并提高催化效率，手性配体在反应过程中配体交换。通过核磁二维谱图等手段分析活性中间体构型以及设计配体调节反应决速步。
2016.7 – 2017.12, Cornell University, Department of Chemistry and Chemical Biology, 博士后
导师: Prof. Song Lin
导师: Prof. Song Lin
研究领域：钛配合物催化的自由基反应（主要研究三元环与烯烃的环加成反应及其不对称催化反应）
离组去向：中国科公司化学研究所 研究员
发表论文：
1. Wei Hao, Katherine L. Bay, Caleb F. Harris, Daniel S. King, Ilia A. Guzei, Michael M. Aristov, Zhe Zhuang, R. Erik Plata, David E. Hill, K. N. Houk, John F. Berry, Jin-Quan Yu, and Donna G. Blackmond, Probing Catalyst Speciation in Pd-MPAAM-Catalyzed Enantioselective C(sp3)-H Arylation: Catalyst Improvement via Destabilization of Off-Cycle Species.
ACS Catal. 2021, 11, 11040-11048.
2. Yazhong Huang†, Kyle W. Knouse†, Shenjie Qiu†, Wei Hao‡, Natalia M. Padial‡ Julien C. Vantourout‡, Bin Zheng, Stephen E. Mercer, Javier O. Lopez, Rohan Narayan, Richard E. Olson, Donna G. Blackmond, Martin D. Eastgate, Michael A. Schmidt, Ivar M. McDonald, and Phil S. Baran, A P(V)-Platform for Oligonucleotide Synthesis.
2. Yazhong Huang†, Kyle W. Knouse†, Shenjie Qiu†, Wei Hao‡, Natalia M. Padial‡ Julien C. Vantourout‡, Bin Zheng, Stephen E. Mercer, Javier O. Lopez, Rohan Narayan, Richard E. Olson, Donna G. Blackmond, Martin D. Eastgate, Michael A. Schmidt, Ivar M. McDonald, and Phil S. Baran, A P(V)-Platform for Oligonucleotide Synthesis.
Science, 2021 (accepted). (†, ‡Authors contributed equally.)
3. Yang Gao, David E. Hill, Wei Hao, Brendon J. McNicholas, Julien C. Vantourout, Ryan G. Hadt, Sarah E. Reisman, Donna G. Blackmond, and Phil S. Baran, Electrochemical Nozaki–Hiyama–Kishi Coupling: Scope, Applications, and Mechanism.
J. Am. Chem. Soc. 2021. 143, 9478-9488.
4. Yan-Qiao Chen, Sukriti Singh, Yongwei Wu, Zhen Wang, Wei Hao, Pritha Verma, Jennifer X. Qiao, Raghavan B. Sunoj, Jin-Quan Yu, Pd-Catalyzed γ‑C(sp3)−H Fluorination of Free Amines.
4. Yan-Qiao Chen, Sukriti Singh, Yongwei Wu, Zhen Wang, Wei Hao, Pritha Verma, Jennifer X. Qiao, Raghavan B. Sunoj, Jin-Quan Yu, Pd-Catalyzed γ‑C(sp3)−H Fluorination of Free Amines.
J. Am. Chem. Soc. 2020, 142, 9966-9974.
5. Wei Hao, Johannes H. Harenberg, Xiangyu Wu, Samantha N. MacMillan, and Song Lin, Diastereo- and Enantioselective Formal [3+2] Cycloaddition of Cyclopropyl Ketones and Alkenes via Ti-Catalyzed Radical Redox Relay.
J. Am. Chem. Soc. 2018, 140, 3514-3517.
6. Xiangyu Wu, Wei Hao, Ke-Yin Ye, Binyang Jiang, Gisselle Pombar, Zhidong Song, and Song Lin, Ti-Catalyzed Radical Alkylation of Secondary and Tertiary Alkyl Chlorides Using Michael Acceptors.
J. Am. Chem. Soc. 2018, 140, 14836-14843.
7. Qi Yang, Liang Liu, Yue Chi, Wei Hao, Wen-Xiong Zhang, and Zhenfeng Xi, Rhodium-Catalyzed Intramolecular Carbosilylation of Alkynes via C(sp3)–Si Bond Cleavage.
Org. Chem. Front. 2018, 5, 860-863.
8. Wei Hao, Xiangyu Wu, James Z. Sun, Juno C. Siu, Samantha N. MacMillan, and Song Lin, Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N‑Acylaziridines and Alkenes.
8. Wei Hao, Xiangyu Wu, James Z. Sun, Juno C. Siu, Samantha N. MacMillan, and Song Lin, Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N‑Acylaziridines and Alkenes.
J. Am. Chem. Soc. 2017, 139, 12141-12144.
9. Jianhao Yin, Qingyu Ye, Wei Hao, Shuaijing Du, Yucheng Gu, Wen-Xiong Zhang, and Zhenfeng Xi, Formation of Cyclopenta[c]pyridine Derivatives from 2,5-Disubstituted Pyrroles and 1,4-Dibromo-1,3-butadienes via Pyrrole-Ring One-Carbon Expansion.
Org. Lett. 2017, 19, 138-141.10. Wei Hao†, Junnian Wei†, Yue Chi, Patrick J. Walsh, Zhenfeng Xi, A DFT Study on Conversion of Aryl Iodides to Alkyl Iodides: Reductive Elimination of R–I from Alkylpalladium Iodide Complexes with Assesable b-Hydrogens.
Chem. Eur. J. 2016, 22, 3422-3429. (†Authors contributed equally.)
11. Wei Hao, Han Wang, Qingyu Ye, Wen-Xiong Zhang, and Zhenfeng Xi, Cyclopentadiene-Phosphine/Palladium Catalyzed Synthesis of Indolizines from pyrrole and alkenyl or aryl dibromides.
Org. Lett. 2015, 17, 5674-5677.
12. Wei Hao, Han Wang, Patrick J. Walsh, and Zhenfeng Xi, Combining Pd (π-allyl) Cp and PPh3 as a Unique Catalyst for Efficient Synthesis of Alkyliodo Indoles via C (sp3)–I Reductive Elimination.
12. Wei Hao, Han Wang, Patrick J. Walsh, and Zhenfeng Xi, Combining Pd (π-allyl) Cp and PPh3 as a Unique Catalyst for Efficient Synthesis of Alkyliodo Indoles via C (sp3)–I Reductive Elimination.
Org. Chem. Front. 2015, 2, 1080-1084.
13. Kunbing Ouyang, Wei Hao, Wen-Xiong Zhang, and Zhenfeng Xi, Transition-Metal-Catalyzed Cleavage of C–N Single Bonds.
Chem. Rev. 2015, 115, 12045-12090.
14. Wei Hao, Junnian Wei, Weizhi Geng, Wen-Xiong Zhang, and Zhenfeng Xi, Transfer of Aryl Halide to Alkyl Halide: Reductive Elimination of Alkylhalide from Alkylpalladium Halide Containing syn-b-Hydrogens.
Angew. Chem. Int. Ed. 2014, 53, 14533-14537.
15. Wei Hao, Weizhi Geng, Wen-Xiong Zhang, and Zhenfeng Xi, Palladium-Catalyzed One-Pot Three- or Four-Component Coupling of Aryl Iodides, Alkynes, and Amines through C-N Bond Cleavage: Efficient Synthesis of Indole Derivatives.
Chem. Eur. J. 2014, 20, 2605-2612.
16. Weizhi Geng, Chao Wang, Jie Guang, Wei Hao, Wen-Xiong Zhang, and Zhenfeng Xi, 1,2,3,4-Tetrasubstituted Cyclopentadienes and Their Applications for Metallocenes: Efficient Synthesis through Zirconocene- and CuCl-Mediated Intermolecular Coupling of Two Alkynes and One Diiodomethane.
Chem. Eur. J. 2013, 19, 8657-8664.
17. Weizhi Geng, Wen-Xiong Zhang, Wei Hao, and Zhenfeng Xi, Cyclopentadiene−Phosphine/Palladium-Catalyzed Cleavage of C−N Bonds in Secondary Amines: Synthesis of Pyrrole and Indole Derivatives from Secondary Amines and Alkenyl or Aryl Dibromides.
J. Am. Chem. Soc. 2012, 134, 20230-20233.
